Abstract: The concentration of pefloxacin was determined in plasma, muscle, hepatopancreas and kidney of FFRC common carpCyprinuscarpiostrain with body weight of (200±30)g challenged by a single intramuscular injection and oral administration at a dose of 10 mg/kg body weight by the ultrahigh performance liquid chromatography at water temperature of 18 ℃, and the data were analyzed by the non-compartmental analysis method of DAS 3.0 pharmacokinetic program software to establish a reasonable withdrawal period for pefloxacin in common carp. The Auc was found to be 88.35 mg·h/L for oral administration and 139.9 mg·h/L for the injection. The elimination half-life(t1/2) was found to be 22.301 h after oral administration and 74.357 h after injection，and the volume of distribution(Vd) 5.464 L/kg for oral administration and 15.342 L/kg for the injection. The peak concentration of the pefloxacin (Cmax) was 2.092 mg/L for oral administration and 3.687 mg/L for the injection, and the peak time(Tmax) 4.0 h for oral administration and 0.5 h for the injection. The total body clearance(CL) of pefloxacin was 0.170 L·kg/h for oral administration and 0.143 L·kg/h for the injection. It is concluded that more quickly absorption, higher peak plasma concentration, higher bioavailability and faster elimination is observed in intramuscular injection compared with the oral administration.
李改娟, 刘艳辉, 祖岫杰, 鞠松柏, 王文兰, 陈伟强, 刘铁钢. 不同给药方式下培氟沙星在鲤体内的药代动力学研究[J]. 大连海洋大学学报, 2014, 29(4): 386-390.
LI Gai-juan, LIU Yan-hui, ZU Xiu-jie, JU Song-bai, WANG Wen-lan, CHEN Wei-qiang, LIU Tie-gang. Pharmacokineticsofpefloxacinincommoncarpchallengedbyasingleintramuscularinjectionandoraladministration. Journal of Dalian Ocean University, 2014, 29(4): 386-390.
2014, Vol. 29 
