Abstract: The acute toxicity of sodium pentachlorophenate(PCP-Na)to crucian carp Carassius auratus with body weight of(22±2)g were studied at various concentrations at water temperature of(25±0.5)℃using a laboratory test.The animals were all found to be died at the drug concentration of 10 mg/L after 1 h administration,PCP-Na showing strong acute toxicity.At the drug concentration of 2 mg/L,however,all the animals were survival and healthy after 96 h administration.The in vivo pharmacokinetics was investigated in the crucian carp bathed in PCP -Na.Promisingly,the drug was quickly absorbed by the animals,11.5 ng/mL PCP-Na was observed in the blood in 0.5 h administration and the peak concentration of 12.0 ng/mL after 1 h administration.The plasma concentration of PCP-Na was detected for up to 70 days and in very trace quantities,and thereafter no drug was found.The pharmacokinetics in the muscle was shown to be similar to that in the blood,the peak(11.84 ng/mL)in the muscle after 1 h administration,lower than that in the blood.It was found that the t1/2αwas 12.6 h,t1/2β186.8 h, MRT0-t260.4 h,Tmax1 h,Cmax11.84 ng/mL,AUC0-t1106.5 ng/(mL·h)and MAT 222.5 h in the muscle.
2012, Vol. 27 
