Abstract: The common carpCyprinus carpiowith body weight of(200±30)g were randomly divided into two groups and administered orally with enrofloxacin and combination of enrofloxac in and gallic acid(mass ratio of 10∶1)at a dose of 2 mg/kg(body weight)atwater temperature of26℃to study pharmacokinetics and residues of enrofloxacin in common carp.Then the concentration of enrofloxacin were detected in plasma,muscle,hepatopancreas and kidney sampled in different time by high performance liquid chromatography with fluorescence detection.The non-compartmental analysis by DAS 3.0 pharmacokinetic program software revealed that gallic acid led to increase the absorption efficiency of enrofloxacin significantly,to improve the effective drug concentration from 20.0％to 44.9％,and to facility themetabolism and elimination of the drug,reducing the drug residues by 44.2％ in plasma and by 34.1％in muscle in 240 h exposure.
李改娟, 刘艳辉, 陈伟强, 祖岫杰, 戴欣, 赵全东, 杨炳坤. 没食子酸对恩诺沙星在鲤体内的药代动力学及残留的影响研究[J]. 大连海洋大学学报, 2016, 31(6): 658-662.
LIGai-juan, LIU Yan-hui, CHENWei-qiang, ZU Xiu-jie, DAIXin, ZHAO Quan-dong, YANG Bing-kun. Effects of gallic acid on metabolism and residues of enrofloxacin in common carpCyprinus carpio. Journal of Dalian Ocean University, 2016, 31(6): 658-662.
2016, Vol. 31 
