Histopathological effect of norfloxacin on gill arch cartilages in common carp （Cyprinus carpio）
WU Yong-kui, ZHANG jin-xia, LI Qian-xue, LIU Yan-hui, XIA Zhi-ping, ZHANG Zuo-xin
1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China; 2. The Military Veterinary Institute, Academy of Military Medical Sciences, Changehun 130062, China; 3. Jilin Province Fishery Scientific Academy, Changchun 130033, China
Abstract: Tissue distribution and histopathological influence of norfloxacin on gill arch cartilages were investigated in 75 day old common carp （ Cyprinus carpio） using the methods of microassay in the standard agar diffusion in which Escherchia coli ATCC25922 was used as experimental bacterium. The results showed that norfloxacin has powerful affinity with cartilagess of juvenile carp. There was the maximum level of norfloxacin in cartilage, per day ） g cartilage followed by liver, then in muscles. The carp bathed in Norfloxacin for 5 consecutive days （30 min at a dose of 25, 150 or 900 mg/L had detectable histopathological lesions in gill arch cartilages, e. cell necrosis, dissolved, vacuolated at a dose of 150 mg/L, which indicating that more attention should be paid when fluoroquinolones treatment is administrated.
2006, Vol. 21 
