Research progress on Akt gene in aquatic animals:a review
LIU Li;SUN Jing-xian;CHANG Ya-qing;CUI Dong-yao;LI Ying-ying;LI Kai-quan;ZHAN Yao-yao
Key Laboratory of Mariculture & Stock Enhancement in North China s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China
Abstract: Akt(RAC-alpha serine/threonine-protein kinase)as a serine(Ser) or threonine(Thr) protein kinase, known as protein kinase B(PKB, functions as phosphorylation of a variety of transcription factors, and plays an essential rolein cell multiplication, cellular immune response, cell metabolism regulation, cell development and survival. At present, there were few research on Akt gene in aquatic animals, so we reviewed the sequence characteristics, evolutionary characteristics, and main pathways involved in Akt gene in aquatic animals, as well as the biological functions involved in regulation of embryonic development of fish, and immune defense processes of crustaceans and shellfish. In the future, more Akt gene information of aquatic animals can be obtained by homologous cloning or genome data mining technology so as to understand systematically and comprehensively the evolution characteristics and rules of Akt gene in aquatic animals, and to further explore the response rules of Akt gene in different aquatic animals and the interaction mechanism between Akt gene and downstream target genes under different physiological and pathological conditions. Further screening and mining of epigenetic regulators that can regulate Akt gene expression in aquatic animals can provide abundant information and clues for fully understanding and utilizing of the biological functions of Akt gene in aquatic animals.
刘丽, 孙景贤, 常亚青, 崔东遥, 李莹莹, 李开全, 湛垚垚. 水产动物Akt基因研究进展[J]. 大连海洋大学学报, 2019, 34(4): 602-609.
LIU Li, SUN Jing-xian, CHANG Ya-qing, CUI Dong-yao, LI Ying-ying, LI Kai-quan, ZHAN Yao-yao. Research progress on Akt gene in aquatic animals:a review. Journal of Dalian Ocean University, 2019, 34(4): 602-609.
2019, Vol. 34 
