Abstract: Nucleic acid vaccine, also named as DNA vaccine, has become a noval vaccine since 1990s. It has to some extent advantages over conventional vaccines and become one of a worldwide hot - topic. There are many achievements on research associated with this field. The research historical development, immunologic mechanism, process of construction, advantages and disadvantages of DNA vaccine are reviewed in the present paper. In addition, the history and development of DNA vaccine are described in fish, and some useful suggestions are presented for future research on DNA vaccine in fish.
郝贵杰, 沈锦玉, 潘晓义. 核酸疫苗的研究进展及其在鱼类免疫中的应用[J]. 大连海洋大学学报, 2007, 22(2): 142-148.
HAO Gui-jie, SHEN Jin-yu, PAN Xiao-yi. The current development of nucleic acid vaccine and its application in fish: A rievew. Journal of Dalian Ocean University, 2007, 22(2): 142-148.