Fish vaccine technology development and application in China:a review
WANG Qiyao
State Key Laboratory of Bioreactor Engineering,Aquatic Animal Diseases Research Laboratory,Ministry of Agriculture and Rural Affairs,Shanghai Engineering Research Center of Maricultured Animal Vaccine,East China University of Science and Technology,Shanghai 200237,China
Abstract: Aquaculture industries have witnessed large-scale,intensive,professional quick development and diseases outbreaks greatly threaten the healthy sustainable development of the industries.Vaccination can not only prevent and control aquatic diseases,reduce the economic loss of aquaculture industry,but also reduce the health hazards and ecological risks brought about by overuse and abuse of antibiotics,which meets the needs of green development of aquaculture industry in China.We reviewed the main stream technologies used for the development,and inoculation strategies and associated delivery methods of vaccines against piscine species,e.g.inactivated vaccines,live attenuated or live avirulent vaccines,subunit vaccines or synthetic peptide vaccine,as well as DNA vaccines.Nine vaccines related to aquatic diseases that have been fully licensed new veterinary drug registration’s certificate in China are described.The overview of administration management of Chinese aquaculture and aquatic vaccines is also introduced in recent years.In addition,the future prospects of development and engineering of piscine vaccines are discussed,including the basic research for fish pathogens and diseases control,molecular design of fish vaccines by leveraging multi-omics technologies,and construction of piscine vaccine engineering and technology platform to facilitate to provide effective vaccines for diseases control in China aquaculture industries.
王启要. 中国鱼类疫苗技术研发及应用研究进展[J]. 大连海洋大学学报, 2022, 37(1): 1-9.
WANG Qiyao. Fish vaccine technology development and application in China:a review. Journal of Dalian Ocean University, 2022, 37(1): 1-9.
2022, Vol. 37 
