Abstract: Acute toxicity of several disinfectants and antibiotics to juvenile sea cucumber Apostichopus japonicus was determined. It was found that the acute toxicity of the medicines to sea cucumber juveniles in a descent order ranged as oxytetracycline > norfloxacin > sulfamethoxazole. Medium lethal concentration (LC 50) in 24, 48 h of oxytetracycline is 166 mg/L, and 115 mg/L with safe concentration(SC) of 16.56 mg/L , respectively; LC 50 in 24,48 h of norfloxacin is 457, 407 mg/L, respectively, and safe concentration(SC)is 96.9 mg/L; LC 50 in 48, 72 h of sulfamethoxazole is 300, 224 mg/L, respectively. The toxicity sequence of the disinfectants to sea cucumber juveniles in a descent order ranged as chlorine dioxide > potassium permanganate > formalin > sodium chlorite > dipterex. The 24 h LC 50 of chlorine dioxide is 0.36 mg/L; the 24,48 h, and 72 h LC 50 of potassium permanganate is 3.02,2.09,1.26 mg/L, respectively, with SC of 0.23 mg/L; the 24, 48 h,and 72 h LC 50 of formalin is 8.71×10 -6,4.37×10 -6, 1.62×10 -6, respectively, with SC of 0.33×10 -6; the 24, 48, 72 h ,and 96 h LC 50 of sodium chlorite is 44.7×10 -6,14.5×10 -6,10.0×10 -6, and 9.3×10 -6, respectively, with a SC of 8.46 mg/L; the 24,48,72 h,and 96 h LC 50 of dipterex is 479,158,105,78 mg/L, respectively, with a SC of 6.49 mg/L. The feasibility of several common disinfectants and antibiotics in the culture of the sea cucumber was discussed.
李强, 罗永成, 李华, 常亚青. 常用抗菌药物和消毒剂对刺参幼体的急性毒性试验[J]. 大连海洋大学学报, 2005, 20(2): 105-110.
LI Qiang, LUO Yong-cheng, LI Hua, CHANG Ya-qing. Acute toxicity of common antibiotics and disinfectants to juvenile sea cucumber (Apostichopus japonicus). Journal of Dalian Ocean University, 2005, 20(2): 105-110.
2005, Vol. 20 
