Functional effect of dietary fiber from seaweed Costaria costata residues on reduce in serum lipids in mice
FU Hui,WANG Qiu-kuan,HE Yun-hai,REN Dan-dan
Key Laboratory of Fishery Product Processing and Utilization of Liaoning Province,Dalian Ocean University,Dalian 116023,China,National Research &Development Center for Seaweed Processing,Dalian Ocean University,Dalian 116023,China
Abstract: A total of 140 mouse was fed diets containing 5%,10%,and 15%of seaweed Costaria costata residues,fiber(DF)from the seaweed residues,and high lipid for 4 weeks to evaluate the functional effect of dietary fiber(DF)from the seaweed residues on reduce in serum lipids in the mouse by monitoring of total serum cholesterol(TC),total triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fecal cholesterol(FC)and liver fat(LF)contents,atherosclerosis index(AI),liver index and spleen index.The results showed that the high-fat model was found in the mouse fed the diet containing high lipid.The insoluble dietary fiber(IDF)and mixed DF with high dose were found to lead to significant reduce in the TC and TG levels(P＜0.05),and the mixed DF with medium dose lower to result in significant reduce in the TC level(P＜0.05).There were significantly lower LDL-C,AI levels and LF content in the mouse fed the diets containing IDF, soluble dietary fiber(SDF),mixed DF and the sea weed residues with low,medium and high dose(P＜0.05),while the HDL-C level was improved and the excretion of FC was accelerated(P＜0.05).There was significantly lower liver index in the mouse fed the diets containing IDF with medium and high dose and significantly higher spleen index in the mouse fed the diets containing SDF,mixed DF various and the seaweed residues with high dose(P＜0.05).Therefore,DF from the seaweed residues shows an effect on reducing serum lipids and can be applied in preventing atherosclerosis and coronary heart disease.
付慧, 汪秋宽, 何云海, 任丹丹. 多肋藻渣膳食纤维对小鼠降血脂作用的研究[J]. 大连海洋大学学报, 2012, 27(3): 200-204.
FU Hui, WANG Qiu-kuan, HE Yun-hai, REN Dan-dan. Functional effect of dietary fiber from seaweed Costaria costata residues on reduce in serum lipids in mice. Journal of Dalian Ocean University, 2012, 27(3): 200-204.
2012, Vol. 27 
