Effects of a mixture of seaweed fucoidan combined with hawthorn extracts on hypercholesterolemia WANG Ya-fang, WANG Qiu-kuan, HE Yun-hai, REN Dan-dan
WANG Ya-fang, WANG Qiu-kuan, HE Yun-hai, REN Dan-dan,LIN Ru，SONG Yue-fan, CONG Hai-hua
College of Food Science and Engineering, National Research & Development Branch Center For Seaweed Processing, Key Laboratory of Aquatic Product Processing and Utilization of Liaoning Province, Dalian Ocean University, Dalian 116023, China
Abstract: The effects of the mixture of seaweed fucoidan combined with hawthorn extracts on hypercholesterolemia were investigated in mice fed high-fat diet. The fucoidan extracted from seaweed Kjellmaniella crassifolia and Undaria pinnatifida was mixed with hawthorn extracts in the ratio of 1∶1 and intragastrically administrated in the mice with body weight of 150-170 g for 28 days. The results showed that the mice fed the mixture at low and high doses had significant decrease in the levels of serum total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) and atherosclerotic index (AI) (P<0.05). In vitro analysis of antioxidant enzyme activity revealed that there was significantly higher glutathione peroxidase (GSH-Px) activity in the mice fed the mixture at low and high doses (P<0.05). The findings indicate that the mixture had good effect on hypercholesterolemia, without dose-dependence.
王亚芳, 汪秋宽, 何云海, 任丹丹, 林茹, 宋悦凡, 丛海花. 褐藻多糖硫酸酯与山楂提取物混合剂的降血脂作用[J]. 大连海洋大学学报, 2015, 30(3): 309-313.
WANG Ya-fang, WANG Qiu-kuan, HE Yun-hai, REN Dan-dan, LIN Ru, SONG Yue-fan, CONG Hai-hua. Effects of a mixture of seaweed fucoidan combined with hawthorn extracts on hypercholesterolemia WANG Ya-fang, WANG Qiu-kuan, HE Yun-hai, REN Dan-dan. Journal of Dalian Ocean University, 2015, 30(3): 309-313.
2015, Vol. 30 
