Application of Norfloxacin in treatment of bacterial diseases in fishes
ZHANG Ya bin,ZHANG Zuo xin,ZHENG Wei,LIU Yan hui
1 Jilin Privince Aquatic Scientific Institute, Changchun 130051; 2 Military Veterinary Institute, University of Agriculture and Animal Sciences, Changchun 130
Abstract: Norfloxacin of the seven bacteriostasis drugs tested is the highest sensitive (MIC \%ρ\%<0 2 μg/mL) to Noxfloxacin pathogenic bacteria infection bacterial hemorrhagic septicemia in Carp The experiment of internal antic-bacteria effect showed that Norfloxacin either injected into the fish at 1 mg/kg or oral administration at 10 mg/kg has the desired action such as improving the survival rate of infected fish. The effect of pharmacokinetics research shows that the drug level in the fish's blood is upto 0 2 μg/mL, during the course of taking drug mixed in diet 0 75 h to 24 h On the basis of the experiment, the administration of drug is established, that is, the dose orally is 10 mg/kg, at the intervals of 24 h for 5 times The effect applied in production is good The poisonous test, pouring impatientty Norfloxacin down the throat with Carp, shows LD\-\{50\}>1000 mg/kg (96 h) There was no remains of the Norfloxacin in the muscle after administration of 144 h.
张雅斌, 张祚新, 郑伟, 刘艳辉. 诺氟沙星在鱼类细菌性疾病中的应用研究[J]. 大连海洋大学学报, 2000, 15(2): 79-85.
ZHANG Ya bin, ZHANG Zuo xin, ZHENG Wei, LIU Yan hui. Application of Norfloxacin in treatment of bacterial diseases in fishes. Journal of Dalian Ocean University, 2000, 15(2): 79-85.
2000, Vol. 15 
