Abstract: Two compounds were isolated from sponge Craniella australiensis by column chromatography on silica gel and gel filtration chromatography，and identified by spectroscopic analysis and physical-chemistry property to evaluate the application of the sponge in preparation of marine drugs.The inhibition on tumor cells of both extracts from the sponge was evaluated by CCK-8 assay.The results showed that the two compounds were identified as Aldisin and 2-Bromoaldisin which exhibited the potent inhibitory activities against Caco-2，HCT116，7721，U251 and A495 cells in human.The Aldisin showed the strongest cytotoxic activity against 7221 cell with IC50（67.56±3.06）μg/mL.The findings indicate that the extracts as natural products are considered as a potential anti-tumor candidate for further study.
2016, Vol. 31 
