Pharmacokinetics and residues of allicin in Songpu m irror carp Cyprinus carpio Songpu
PAN Hao1，2，WANG Di1，LU Tong-yan1
1.Heilongjiang River Fisheries Research Institute，Chinese Academy of Fishery Sciences，Harbin 150070，China；2.College of Fisheries and Life Science，Shanghai Ocean University，Shanghai201306，China
Abstract: The pharmacokinetics and residues of allicin were studied in Songpumirror carp Cyprinus carpio Songpu exposed to oral administration at a dose of 7.5 mg/kg（body weight）at water temperature of（20.0±0.5）℃by means of gas chromatography（GC）.The drug concentrations in plasma weremonitored 0.25，0.50，0.75，1.00，1.50，2.00，4.00，6.00，8.00，12.00，24.00，36.00，48.00 h，and 72.00 h after drug administration，and analyzed by DAS 3.0 software.The results showed that the concentrations of allicin in muscle versus time were well described by two-department openmodelwith first-order absorption after a single oral administration.The residues in Songpu mirror carp by oral administration for 3 d once a day was found to be less than the maximal residue limit（MRL）（10μg/kg）at the day 15 for DADS and DATS.The findings indicate that the withdrawal time should be 15 d after administration under these conditions.
潘浩, 王荻, 卢彤岩. 大蒜素在松浦镜鲤体内的药动学及残留消除规律[J]. 大连海洋大学学报, 2016, 31(5): 505-509.
PAN Hao, WANG Di, LU Tong-yan. Pharmacokinetics and residues of allicin in Songpu m irror carp Cyprinus carpio Songpu. Journal of Dalian Ocean University, 2016, 31(5): 505-509.
2016, Vol. 31 
