Pharmacokinetics and residues of ofloxacin in GIFT tilapia strain Oreochromis niloticus
WANG Xian-yu1,SONG Jie1,2,WANG Wei-li1,JIANG Lan1,LUO li1,KE jian1,2
1.Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou 510380,China; 2.College of Fisheries and Life Science,Shanghai Ocean University,Shanghai 201306,China
Abstract: The metabolism and elimination of ofloxacin(OFLX)were studied in plasma and tissues of GIFT strain Nile tilapia(Oreochromis niloticus)after oral administration(10 mg/kg body weight)at(25±2)℃by high performance liquid chromatography(HPLC)method.The results showed that the distribution of OFLX in plasma and tissues were described by two open-compartment model with first order absorption with rapid absorption and distribution and slow elimination.The peak time of OFLX were found 0.41 h in plasma,3.19 h in muscle,0.18 h in liver,and 0.59 h in kidney after the oral administration.The peak concentrations of OFLX were observed to be 7.98 μg/mL in plasma,17.24 μg/g in muscle,36.10 μg/g in liver and 46.65 μg/g in kidney.There was higher OFLX level in the liver than that in other tissues and higher OFLX level in the tissues than that in the plasma at the same time.The order of the elimination was descendantly arranged as the following:kidney＞muscle＞liver with T1/2βof 12.90 h,19.45 h and 28.27 h,respectively.According to the maximum residue limit(MRL)of 10 μg/kg in the tissues,it is suggested that the withdrawal period be over 8 d under this experiment condition,that OFLX be orally applied at a dose of 10 mg/kg,in 12 h interval for 2-3 days when the drug is used for bacterial disease in fish.
王贤玉, 宋洁, 王伟利, 姜兰, 罗理, 柯剑. 氧氟沙星在吉富罗非鱼体内的药代动力学及残留的研究[J]. 大连海洋大学学报, 2011, 26(2): 144-148.
WANG Xian-yu, SONG Jie, WANG Wei-li, JIANG Lan, LUO li, KE jian, . Pharmacokinetics and residues of ofloxacin in GIFT tilapia strain Oreochromis niloticus. Journal of Dalian Ocean University, 2011, 26(2): 144-148.
2011, Vol. 26 
