Abstract: The experiment was conducted to study the influence of starvation and refeeding on the energy metabolism in oriental weatherfish Misgurnus anguillicaudatus with initial wet body weight of ( 11.62 ± 2.22) g under (18 ± 0.5 )℃ from April to May, 2004. The results showed that oxygen consumption and CO2 production of the fish starved for 20 days decreased by 31% (from 200 μg/(g · h) to 138 μg/(g · h) ) and 40% (from 200 μg/(g · h) to 120 μg/(g · h)) respectively, while ammonia- N excretion increased by 29.1% (from 6. 049 μg/(g · h) to 7. 808 μg/( g · h) ) if compared with the initial value; In the course of starvation, the ratio of oxygen to nitrogen (O/N) also decreased, which indicated that lipid and protein were used as first energy source, and then mainly consumed protein; the respiratory quotient (RQ) increased first, and then declined. After 5 - day refeeding, all the metabolism parameters including the oxygen consumption, CO2 production, ammonia - N excretion, O/N and RQ turned to increase if compared with those of fish starved for 20 days.