L-amino acid oxidase as an enzyme related to innate immune defense in marine animals:research progress
HOU Yu-lin1, GAO Yan-qi1, JIN Shi-bo1, LI An-xing2,LI Rui-jun1
1.Key Laboratory of Mariculture & Stock Enhancement in North China’s Sea, Ministry of Agriculture, Key Laboratory of Valuable Sea Food Disease Prevention and Control in Dalian, Dalian Ocean University, Dalian 116023, China; 2.Key Laboratory for Aquatic Products Safety, Ministry of Education, State Key Laboratory of Biocontrol of Harmful Organisms and Resourse Utilization,Sun Yat-sen University, Guangzhou 510275, China
Abstract: L-amino acid oxidase (LAAO) as a family of flavoproteins protease containing coenzymes FAD or FMN has been reported to have significant biological functions including antiviral, antibacterial, antifungal, anti-parasitic and anti-tumor activities. So far, LAAO is widely found in nature and has been investigated intensively, especially snake venom LAAO. However, the LAAO isolated from marine animals was few reported. In this paper, structural features, molecular weight, pI value, catalytic specificity, storage stability, distribution, biological functions and heterologous expression of LAAO in marine animals are summarized to provide basic references for further study on LAAO in marine animals.
侯玉林, 高延奇, 金士博, 李安兴, 黎睿君. 免疫防御酶类:海洋动物L-氨基酸氧化酶的研究进展[J]. 大连海洋大学学报, 2017, 32(5): 625-630.
HOU Yu-lin, GAO Yan-qi, JIN Shi-bo, LI An-xing, LI Rui-jun. L-amino acid oxidase as an enzyme related to innate immune defense in marine animals:research progress. Journal of Dalian Ocean University, 2017, 32(5): 625-630.