Abstract: Effects of lectin from sea mustard Undaria pinnatifida on non - specific immunity in kuruma shrimp Penaeus japonicus weighing 6 - 7 g were studied by injection of lectin at a dose of 2.3 mg per individual 24, 48, 72, 96 ,and 120 h after injection. The results showed that the shrimp with injection of lectin had higher activities of hemagglutination, phenoloxidase ( PO), and superoxide dismutase (SOD), alkaline phosphatase (ALP) and lysozyme (LYS) in the serum than those in the control group from 24 to 120 h after injection. The maximum activities of the serum hemagglutination and PO were observed 24 h after injection, which was 8 times and 64 times higher than those in the control group, respectively. The peak activity of SOD, 2.6 times higher than that in the control group, occurred 48 h after injection. The maximal activities of ALP and LYS appeared 72 h after injection, which were 2.6 times and 4.2 times higher than those in the control group, respectively. The maximal antimicrobial activity, higher than that in the control group, was observed 24 h after injection, which was 1.3 times higher than that in the control group. The phagocytosis rate and phagocytosis index of blood cell, higher than control group in 24 - 72 h and 120 h, reached maximum at 72 h, which were 1.2 times and 1.4 times higher than those in the control group, respectively, indicating that sea mustard lectin can enhance the non - specific immunity of the shrimp.