Abstract: The neuroendocrine system plays an important regulatory role in the metabolism,growth,development,reproduction and immunity response of animals.The reciprocal regulatory relationship between the neuroendocrine system and the immune system has been increasingly concerned in the fields of neurology,endocrinology,physiology,immunology and even medicine in recent years.Recently,the structure and function of the neuroendocrine system and its immunomodulatory mechanisms in invertebrates have attracted attention.Molluscs are eucoelomatous animals with abundant diversity,strong adaptability and wide distribution.It is found that molluscs have not yet differentiated into nerve and endocrine organs,but have evolved molecular mechanism similar to the neuroendocrine immune system in vertebrates,which can be a vital model to study the origin and evolution of invertebrate neuroendocrine system.This paper describes the molecular composition and activation mechanism of the molluscan neuroendocrine system and its regulatory effect on the immune response,proposes that the structure,function,regulation mechanism and evolutionary significance of molluscan neuroendocrine system remains significantly concern in the future research,aiming to provide reference for further understanding the evolution of neuroendocrine system and NEI-mediated environmental adaptation mechanism in molluscs.
王玲玲. 贝类神经内分泌系统对免疫应答的调节机制[J]. 大连海洋大学学报, 2022, 37(3): 363-375.
WANG Lingling. Regulatory mechanism of neuroendocrine system on immune response in molluscs:a review. Journal of Dalian Ocean University, 2022, 37(3): 363-375.
2022, Vol. 37 
