Abstract: Bindin as one of the most important gamete recognition proteins is expressed in testis or sperm of male marine organisms, and can specifically recognize the specific receptors on the surface of corresponding eggs, promoting gamete recognition and fusion.It was demonstrated that bindin protein plays an essential role in ensuring the accuracy of fertilization in marine organisms and maintaining the independence and stability of marine species.The fertilization biology and the mechanism of sex selection have been hot concerns in basic aqua-biological studies and aquaculture research in echinoderms as high invertebrates.The current paper reviewed the sequence characters,biological functions and molecular evolution of bindin in echinoderms in order to further understanding of bindin function in gamete recognition and sex selection in echinoderms.