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大连海洋大学学报  2015, Vol. 30 Issue (6): 692-698    DOI: 10.16535/j.cnki.dlhyxb.2015.06.020
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革兰氏阴性细菌Ⅵ型分泌系统的研究进展
张利娟,叶仕根,杨晓宇,王讷言,杜明洋,李华
大连海洋大学农业部北方海水增养殖重点实验室
Research progress of type Ⅵ secretion system of Gram-negative bacteria
ZHANG Li-juan,YE Shi-gen,YANG Xiao-yu,WANG NE-yan,DU Ming-yang,LI Hua
Key Laboratory of Maricuhure & Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Dalian 116023, China
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摘要 细菌的Ⅵ型分泌系统(T6SS)参与了细菌与细菌间、细菌与宿主间的相互作用,在细菌的存活及致病中发挥着重要的作用。本研究中综述了细菌T6SS的发现与命名、结构与组成,调控机制(Fur、σ54依赖性激活因子、表面缔合、群体感应)与作用机制的最新研究进展,并对其下一步的研究方向进行展望。本研究结果可为深入研究细菌T6SS在细菌间及细菌与宿主间的作用机制,研制基于T6SS的疫苗或靶向药物,寻找对细菌T6SS有效的防控措施提供参考。
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张利娟
叶仕根
杨晓宇
王讷言
杜明洋
李华
关键词:  革兰氏阴性细菌  Ⅵ型分泌系统  结构与组成  调控与作用机制    
Abstract: Bacteria Ⅵ secretion system(T6SS) involves in the interaction between the bacteria and bacteria,or bacteria and host,and plays an important role in the survival and pathogenesis of the bacteria.The discovery and terminology,structure and composition,and the regulatory mechanism(Fur,σ54-dependent activators,surface association,quorum sensing) of bacterial T6 SS is reviewed,and the further research aspects is suggested.This review provides the reference for further research on the T6 SS mechanism and looking for T6SS-based vaccine or drugs to prevention and control bacterial diseases.
Key words:  Gram-negative bacterium    T6SS    structure and composition    regulation and mechanism
               出版日期:  2015-12-21      发布日期:  2016-12-30      期的出版日期:  2015-12-21
中图分类号:  Q939.91  
引用本文:    
张利娟, 叶仕根, 杨晓宇, 王讷言, 杜明洋, 李华. 革兰氏阴性细菌Ⅵ型分泌系统的研究进展[J]. 大连海洋大学学报, 2015, 30(6): 692-698.
ZHANG Li-juan, YE Shi-gen, YANG Xiao-yu, WANG NE-yan, DU Ming-yang, LI Hua. Research progress of type Ⅵ secretion system of Gram-negative bacteria. Journal of Dalian Ocean University, 2015, 30(6): 692-698.
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https://xuebao.dlou.edu.cn/CN/10.16535/j.cnki.dlhyxb.2015.06.020  或          https://xuebao.dlou.edu.cn/CN/Y2015/V30/I6/692
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