1.College of Fisheries，Guangdong Ocean University，Zhanjiang 524088，China；2.Clinical Medicine Research Institute of Zhanjiang Central People’s Hospital，Zhanjiang 524045，China；3.Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology of Aquatic Economic Animals，Zhanjiang 524088，China
Abstract: Type Ⅵ secretion system (T6SS) as a protein secretion system exists within varieties of gram-negative bacteria,and plays important roles in virulent factors release, biofilm formation, iron ion uptake, vesicular transport and environmental pressure adaptability, which is crucial for the pathogenesis of aquatic bacterial pathogens such as Vibrioparahaemolyticus, V.alginolyticus, V.harveyi, Aeromonashydrophila, and Edwardsiellatarda. However, the reports regarding the components and functions of T6SS from aquatic pathogenic bacteria are still rare. The latest research progress on biological functions, regulatory mechanisms of T6SS, as well as the biological roles, evolutionary relationships of the key regulator of T6SS-hemolysin coregulatory protein (Hcp) is summarized from several aquatic bacterial pathogens. Several future key directions are proposed including new biofunctional discoveries of T6SS, correlation between T6SS activity and environmental factors, the regulation between T6SS and virulence-related metabolism. This review will help researchers better understand the roles of aquatic animal pathogens T6SS and provide new ideas for further research on pathogenic mechanism and control of bacterial diseases in aquaculture.
伍水龙, 黄瑜, 王蓓, 汤菊芬, 蔡佳, 简纪常. 水生动物病原菌Ⅵ型分泌系统（T6SS）及其溶血素共调节蛋白研究进展[J]. 大连海洋大学学报, 2024, 39(1): 162-171.
WU Shuilong, HUANG Yu, WANG Bei, TANG Jufen, CAI Jia, JIAN Jichang. Research progress on type Ⅵ secretion system (T6SS) and its hemolysin coregulatory protein from pathogenic bacteria in aquatic animals:a review. Journal of Dalian Ocean University, 2024, 39(1): 162-171.
2024, Vol. 39 
