Abstract: In this paper, modified zeolite was prepared by impregnation in cetyltrimethylammonium bromide(CTAB)at different concentrations of 5-30 mmol/L, and surface characteristics of the modified zeolite were observed by scanning electron microscope(SEM), infrared spectrum(FT-IR) and BET. Effects of modified concentration, dose of zeolite, initial concentration of tetracycline(TC), reaction time and pH value on adsorption and degradation properties of TC in aquaculture wastewater were investigated to optimize the conditions of removal of TC in aquaculture wastewater by the modified zeolite. It was found that the best degradation of TC in aquaculture(the maximum adsorption capacity of 79.18 mg/g) wastewater was observed under conditions of the modified concentration of 15 mmol/L at a dose of 0.10 g, initial TC concentration of 15 mg/L, reaction time for 1 h, and pH value of 8, with the removal efficiency of 89.28%. The adsorption thermodynamics and kinetics showed that the adsorption process of CTAB modified zeolite on TC was more consistent with the Langmuir adsorption isotherm equation than Freundlich adsorption isotherm equation(R~2>0.98). The pseudo-second-order kinetic model and the intraparticle diffusion model were more suitable for the process of TC adsorption on modified zeolite by a spontaneous endothermic physical adsorption process. The findings showed that the removal of TC pollution in aquaculture wastewater by CTAB modified zeolite was effectively.