Immunomodulatory effects of enzymolytic products of Perinereis aibuhitensis in immunosuppressed mice

doi:10.16535/j.cnki.dlhyxb.2024-088

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Journal of Dalian Fisheries University ›› 2025, Vol. 40 ›› Issue (1) : 76-85. DOI: 10.16535/j.cnki.dlhyxb.2024-088

Immunomodulatory effects of enzymolytic products of Perinereis aibuhitensis in immunosuppressed mice

LI Lijuan，ZHU Guoping*，CAO Wenhong，CHEN Zhongqin，TAN Mingtang

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Abstract

The enzymolytic products of Perinereis aibuhitesis were used to explore the immunomodulatory effects of P.aibuhitensis in immunosuppressed mice.The immunosuppressed mouse model was established by using cyclophosphamide induction,and the changes in body mass indexes,immune organ indexes,splenic T lymphocyte subset,total white blood cells,and immunoglobulin concentration of mice in the untreated group,model group,and sample group (the enzymolysis products below<5 000,5 to 8 000,>8 000 in P. aibuhitensis) were measured.The results showed that the three ultrafiltration components of enzymolytic products from P. aibuhitensis could increase the immune organ indexes of mice,the number of CD3e+ on T cells in the spleen,and the concentration of immunoglobulin,all of which have particular immune functions.The high dose of enzymolytic products below<5 000 in P. aibuhitensis showed the highest efficacy and significantly increased the body mass indexes,immune organ indexes,and total white blood cells (P<0.05) of the mice.And the number of CD3e+ and the ratio of CD4+/CD8a+ were significantly increased (P<0.01) and the effect of plasma cells on immunoglobulin secretion was enhanced.Perinereis aibuhitensis can ameliorate the immune impairment induced by immunosuppressants and enhance the immunomodulatory effect in immunosuppressed mice and therefore has the potential for development as an immunomodulator.

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Perinereis aibuhitensis / enzymolytic products / immunomodulation / immunosuppressed mice

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LI Lijuan, ZHU Guoping, CAO Wenhong, CHEN Zhongqin, TAN Mingtang. Immunomodulatory effects of enzymolytic products of Perinereis aibuhitensis in immunosuppressed mice[J]. Journal of Dalian Fisheries University, 2025, 40(1): 76-85 https://doi.org/10.16535/j.cnki.dlhyxb.2024-088