Preparation and temperature response properties of 2-hydroxy-3-butoxypropyl hydroxyethyl cellulose
DAI Ming-yun;TIAN Ye;LIU Ying
College of Marine Science and Environment, Dalian Ocean University, Dalian 116023, China;Liaoning Aquacultural Engineering Research and Development Center, Dalian 116023, China;Pilot National Laboratory for Marine Science and Technology, Qingdao 266200, China
Abstract: 2-hydroxy-3-butoxypropyl hydroxyethyl cellulose(HBPEC) with temperature responsiveness was prepared using hydroxyethyl cellulose(HEC) as a hydrophilic polymer backbone by grafting of hydrophobic agent butyl glycidyl ether(BGE) onto the hydroxyethyl cellulose backbone by etherification reaction, and suitable hydrophilic and lipophilic balance of hydroxyethyl cellulose adjusted by regulation of substitution of the hydrophobic allyl group. The structure of HBPEC was characterized by nuclear magnetic resonance(1HNMR), and effects of solvent, alkali, reaction temperature and reaction time on the molar substitution(MS) and reaction efficiency(RE) of HBPEC synthesis are studied. The best reaction of HBPEC was observed under conditions of the ratio of m(H2O)∶m(AGU)=6, n(NaOH)∶n(AGU)=1.8, reaction temperature of 90 ℃ and reaction for 9 h. HBPEC with different molar substitution degree(MS) had different lower critical solution temperature(LCST) which was decreased with the increase in MS. The LCST was decreased from 44.6 ℃ to 24.1 ℃ as the MS of HBPEC was increased from 0.98 to 2.32. In this study, the thermoresponsive cellulose-based functional material is obtained, which provides a new way for the application of the functional material in drug delivery, biology and other fields.
代明允, 田野, 刘鹰. 2-羟基-3-丁氧基丙基羟乙基纤维素的制备及温度响应性能研究[J]. 大连海洋大学学报, 2019, 34(3): 444-449.
DAI Ming-yun, TIAN Ye, LIU Ying. Preparation and temperature response properties of 2-hydroxy-3-butoxypropyl hydroxyethyl cellulose. Journal of Dalian Ocean University, 2019, 34(3): 444-449.
2019, Vol. 34 
